Archive for September, 2015

25
Sep

Viagra Alternatives at Canadian Health and Care Mall Pharmacy: Kamagra, Cialis

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Erectile dysfunction, sometimes referred to as impotence, is a nightmare for many men, but it affects most of them sooner or later. There is nothing to be ashamed of because this medical condition is widespread and easy to treat, you only need to determine its underlying causes and effective meds. It’s all about your inability to keep or get an erection firm enough for having a sexual intercourse. Canadian Health and Care pharmacy www.acanadianhealthcaremall.com sells Viagra and its popular and more affordable alternatives to men who suffer from ED, and they all are of the best quality.

5 Factors That Cause ED

Viagra Alternatives at Canadian Health and Care Mall Pharmacy: Kamagra, Cialis

1. Endocrine problems. Your endocrine system produces hormones which are necessary to regulate sexual functions, and that’s why such diseases as diabetes can cause impotence.

2. Neurological disorders (spinal tumors, stroke, multiple sclerosis and others) increase the risk of having erectile dysfunction because they affect the ability of your brain to communicate with the sexual system, thus, preventing you from getting a firm erection.

3. Taking certain medications (beta-blockers, depressants, stimulants, synthetic hormones, alpha-adrenergic blockers) affects your blood flow and results in experiencing erectile difficulties, and that’s why you should never take them without the permission of your healthcare provider.

4. Heart conditions affect the ability to pump blood properly, so that they also may cause ED or impotence because you can’t get an erection without enough blood flow. For example, if you suffer from hypertension, high cholesterol levels and atherosclerosis, you have a higher risk for erectile dysfunction.

5. Emotional disorders and bad lifestyle habits. All men go through the excitement phase before achieving an erection, which is their emotional response. If you have emotional disorders, such as anxiety, fatigue or depression, it’s hard to be sexually excited.

How Does Cialis Work?

Cialis is a hot trend at the moment because of its unique effects and incredible characteristics that make it number one choice of many men who suffer from ED. This medication is a PDE5 inhibitor that helps to relax penis muscles and provides enough blood flow into it to achieve an erection. Its effects can last up to 36 hours, and you can take it with or without food only 20 minutes before a sexual intercourse. Other ED meds can’t boast the same effects, and that’s why Cialis is worth your attention and investment, so find out more about its extra benefits.

• Increasing Nitric Oxide levels in your blood, and this means that it flows much better, your oxygen delivery is improved, and your muscles receive more nutrients, thus, making you feel healthier.
• Lowering blood pressure (you shouldn’t take Cialis with other blood pressure meds, such as alpha-blockers and ACE inhibitors).
• Improving your enlarged prostate health by reducing inflammation.

Most Popular Generic Form of Viagra

Want to enjoy the benefits of this famous ED drug, but can’t afford paying its high price? The good news is that you can order Generic Viagra at our website and save money while solving your erectile problems. Kamagra uses the same Sildenafil citrate original formula, is manufactured in India and has GMP certificates. It works by inhibiting the enzyme responsible for having enough blood flow in your penis, thus, improving an erection. Keep in mind that this medication was developed as hypertension treatment, but now it’s used to solve erectile problems worldwide. Kamagra is available as blue diamond-shaped tablets that come in 1 or 4-pill packs, and its recommended dosage is 50 mg a day taken 1 hour before sex.

Generic Viagra, Kamagra, Cialis and other ed medications online at Canadian Health and Care Mall.

25
Sep

Antidiabetic effect of extracts of the seeds of Citrullus lanatus

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INTRODUCTION

The current epidemic of diabetes mellitus (DM) in Africa, coupled with impinging poverty, clearly indicates the urgent need to develop new therapeutic drugs of cheaper and more available to face this growing health challenge. A number of plants products among which the protein-rich seeds including Citrullus lanatus, Telfairia occidentalis, Lagenaria siceraria, Cucumeropsis mannii and Cucurbita moschata are commonly used in traditional medicine with increasing acclaimed efficacy against DM (Teugwa et al., 2013). Diabetes mellitus is a major illness of the human race implicated with numerous clinical manifestations. It is a clinical syndrome characterized by chronic hyperglycemia (defects in insulin secretion, insulin action or both) resulting in aberration in carbohydrate, fat and protein metabolism. It has been reported that the chronic hyperglycemia of diabetes is associated with complications like renal failure, coronary artery disorder, neurological complications, cerebrovascular disease, blindness, and limb amputation, long term dysfunctions and failure of various organs and eventually premature death).

According to the World Health Organization (WHO) projections, the diabetes population is likely to increase to 300 million or more by the year 2025. The high cost of conventional drugs and their unavailability in many rural areas, coupled with their high incidence of side effects, posed a dare need for a change of the affair in case of modern medicine. Thus, the management of diabetes without any side effect is still a major challenge. According to the WHO, approximately 80% of the world’s population currently uses herbal medicines in healing different ailments. However, among the estimated 400,000 plant species, only 6% have been studied for biological activity, and about 15% have been investigated phytochemically. This shows a need for planned activity guided phyto-pharmacological evaluation of herbal drugs. The aim of this study was to phytochemically analyse and evaluate the antidiabetic activity of the seeds of Citrullus lanatus.

MATERIALS AND METHODS

Plant material

Seeds of Citrullus lanatus were collected from Unguwar Rimi market, Kaduna north, Kaduna. The seeds were bench dried for eleven days and pulverized into coarse powder and kept in polythene bags at room temperature, ready for extraction.

Extraction of plant material

The dried pulverized seed (300g) was macerated with 1000 mls of petroleum ether (60-80 °C) for three days at room temperature and filtered and this was repeated twice. The combined filtrate was distilled using a rotary evaporator and then air-dried to obtain the petroleum ether extract. This procedure was repeated using ethanol on the residue of the seeds and after filtration the combined filtrate was then distilled to afford the ethanol extracts. Sildenafil Citrate in Discount Canadian Store. Watch on this website: mycanadianpharmacyrx.com.

Phytochemical screening

Phytochemical screening was carried out on the two extracts (petroleum ether and ethanol) of Citrullus lanatus peel using standard procedures and tests (Trease and Evans, 1989; Sofowora, 1993) to determine the presence of alkaloids, tannins, terpenoids, flavonoids, reducing sugar, anthraquinones, and saponins.

Pharmacological study

Animals

White albino mice (22-32g) of both sexes obtained from biochemistry department Kaduna state University, Kaduna were used for the experiment. The animals were kept under standard environmental conditions of temperature, relative humidity, and fed with standardized pellets and water ad libitum during the period in aluminum cages. The mice were fasted for 12hrs before experimentation but were allowed free access to water.

Experimental design

Hyperglycemia was induced by intraperitoneal injection of 150mg/kg body weight alloxan monohydrate, freshly dissolved in regular saline 0.9% physiological saline immediately before use, to overnight fasted albino mice. After 7 days, animals with fasting blood glucose level ≥126 mg/dl (≥7.0 mmol/dl) or more were considered diabetic and employed in the study. The mice were then grouped into 5 groups of five mice each as follows:

Group 1: Served as positive control and received glibenclamide (2 ml/kg body weight)
Group 2: Served as negative control receiving physiological saline (10 ml/kg)
Group 3: Received petroleum ether extract at 150 mg/kg body weight
Group 4: Received petroleum ether extract at 200 mg/kg
Group 5: Received petroleum ether extract at 250 mg/kg
Group 6: Received ethanol extract at 150 mg/kg body weight
Group 7: Received ethanol extract at 200 mg/kg Group 8: Received ethanol extract at 250 mg/kg

The animals were treated once with each dose and fasting blood glucose concentrations were measured at 0, 1, 3, 6 and 12 hours. Blood samples were taken by a snip-cut at the tip of the tail and blood sugar level was measured with a glucometer (a ONE TOUCH Ultra easy blood glucose monitoring system. Twitter Canadian Pharmacy – hot infortmation about sexual health, discounts in best Canadian Pharmacies.

Statistical Analysis

All the values of fasting blood glucose were expressed as mean ± SEM (n=5) and statistical significances between the treated and control groups (glibenclamide and physiological saline) were analyzed by means of Student’s t-test; P values <0.05 were considered significant.